CFTR – Linking physiology, regulation and structure

Sponsored by The Journal of Physiology

The anion channel cystic fibrosis transmembrane conductance regulator (CFTR) is found in epithelial cells lining ducts and tubes throughout the body where it plays a key role in controlling the quantity and composition of epithelial secretions.  Malfunction of CFTR causes the common genetic disease cystic fibrosis (CF).  This symposium will discuss recent developments in understanding (i) the function of CFTR in different epithelial tissues, (ii) the relationship between CFTR structure and function, especially how the nucleotide-binding domains (NBDs) and regulatory domain (RD) control channel gating and (iii) the action of small-molecules that restore channel function to CF mutants.